IMA4_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: KPNA3 , QIP2
Protein names and data: IMA4_HUMAN , Importin subunit alpha-4 , Importin alpha Q2; Qip2; Karyopherin subunit alpha-3; SRP1-gamma Lenght: 521 a.a.
Mass: 57811 Da
fasta formatted sequence
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).
Tissue specificity: Ubiquitous. Highest levels in heart and skeletal muscle.

Genetic variants

Database cross-references

UniProt: O00505
Ensembl: ENST00000261667
MIM: 601892
neXtProt: NX_O00505
Antibodypedia: O00505 (may not find the protein thus also not any antibody)
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