IMA5_HUMAN

Source: PM19886704
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: KPNA1 , RCH2
Protein names and data: IMA5_HUMAN , Importin subunit alpha-5 , Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-beta; Importin subunit alpha-5, N-terminally processed Lenght: 538 a.a.
Mass: 60222 Da
fasta formatted sequence
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed ubiquitously.

Genetic variants

Database cross-references

UniProt: P52294
Ensembl: ENST00000344337
MIM: 600686
neXtProt: NX_P52294
Antibodypedia: P52294 (may not find the protein thus also not any antibody)
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