IMDH2_HUMAN

Source: hRBCD ; ID: IPI00291510
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: IMPDH2 , IMPD2
Protein names and data: IMDH2_HUMAN , Inosine-5'-monophosphate dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; 1.1.1.205 , IMPDH-II Lenght: 514 a.a.
Mass: 55805 Da
fasta formatted sequence
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Catalytic activity: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Database cross-references

UniProt: P12268
Ensembl: ENST00000326739
MIM: 146691
neXtProt: NX_P12268
Antibodypedia: P12268 (may not find the protein thus also not any antibody)
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