IMPA1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IMPA1 , IMPA
Protein names and data: IMPA1_HUMAN , Inositol monophosphatase 1; IMP 1; IMPase 1; 3.1.3.25 , Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1 Lenght: 277 a.a.
Mass: 30189 Da
fasta formatted sequence
Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Catalytic activity: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Pathway: Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: P29218
Ensembl: ENST00000256108
Ensembl: ENST00000311489
Ensembl: ENST00000449740
MIM: 602064
neXtProt: NX_P29218
Antibodypedia: P29218 (may not find the protein thus also not any antibody)
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