IMPCT_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IMPACT
Protein names and data: IMPCT_HUMAN , Protein IMPACT , Imprinted and ancient gene protein homolog Lenght: 320 a.a.
Mass: 36476 Da
fasta formatted sequence
Function: Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).
Cellular location: Cytoplasm (By similarity). Note=May be associated with polysomes (By similarity).
Tissue specificity: Widely expressed. Expressed at high level in brain.

Genetic variants

Database cross-references

UniProt: Q9P2X3
Ensembl: ENST00000284202
MIM: 615319
neXtProt: NX_Q9P2X3
Antibodypedia: Q9P2X3 (may not find the protein thus also not any antibody)
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