INO1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ISYNA1 , INO1
Protein names and data: INO1_HUMAN , Inositol-3-phosphate synthase 1; IPS 1; 5.5.1.4 , Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase; hIPS; Myo-inositol 1-phosphate synthase A1; hINO1 Lenght: 558 a.a.
Mass: 61068 Da
fasta formatted sequence
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
Catalytic activity: D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate.
Pathway: Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.

Database cross-references

UniProt: Q9NPH2
Ensembl: ENST00000338128
Ensembl: ENST00000457269
Ensembl: ENST00000578963
MIM: 611670
neXtProt: NX_Q9NPH2
Antibodypedia: Q9NPH2 (may not find the protein thus also not any antibody)
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