INP5K_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: INPP5K , PPS, SKIP
Protein names and data: INP5K_HUMAN , Inositol polyphosphate 5-phosphatase K; 3.1.3.56 , Skeletal muscle and kidney-enriched inositol phosphatase Lenght: 448 a.a.
Mass: 51090 Da
fasta formatted sequence
Function: Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
Cellular location: Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles.
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.

Genetic variants

Database cross-references

UniProt: Q9BT40
Ensembl: ENST00000320345
Ensembl: ENST00000406424
Ensembl: ENST00000421807
MIM: 607875
neXtProt: NX_Q9BT40
Antibodypedia: Q9BT40 (may not find the protein thus also not any antibody)
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