IPO11_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IPO11 , RANBP11
Protein names and data: IPO11_HUMAN , Importin-11; Imp11 , Ran-binding protein 11; RanBP11 Lenght: 975 a.a.
Mass: 112535 Da
fasta formatted sequence
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
Cellular location: Cytoplasm. Nucleus.

Genetic variants

Database cross-references

UniProt: Q9UI26
Ensembl: ENST00000325324
Ensembl: ENST00000409296
MIM: 610889
neXtProt: NX_Q9UI26
Antibodypedia: Q9UI26 (may not find the protein thus also not any antibody)
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