IPO4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IPO4 , IMP4B, RANBP4
Protein names and data: IPO4_HUMAN , Importin-4; Imp4 , Importin-4b; Imp4b; Ran-binding protein 4; RanBP4 Lenght: 1081 a.a.
Mass: 118715 Da
fasta formatted sequence
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).

Genetic variants

Database cross-references

UniProt: Q8TEX9
Ensembl: ENST00000354464
neXtProt: NX_Q8TEX9
Antibodypedia: Q8TEX9 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.