IPO5_HUMAN

Source: hRBCD ; ID: IPI00329200
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: IPO5 , KPNB3, RANBP5
Protein names and data: IPO5_HUMAN , Importin-5; Imp5 , Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5; RanBP5 Lenght: 1097 a.a.
Mass: 123630 Da
fasta formatted sequence
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Cellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

Genetic variants

Database cross-references

UniProt: O00410
Ensembl: ENST00000261574
Ensembl: ENST00000357602
Ensembl: ENST00000490680
MIM: 602008
neXtProt: NX_O00410
Antibodypedia: O00410 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.