IPO9_HUMAN

Source: hRBCD ; ID: IPI00185146
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: IPO9 , IMP9, KIAA1192, RANBP9 , HSPC273
Protein names and data: IPO9_HUMAN , Importin-9; Imp9 , Ran-binding protein 9; RanBP9 Lenght: 1041 a.a.
Mass: 115963 Da
fasta formatted sequence
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).

Database cross-references

UniProt: Q96P70
Ensembl: ENST00000361565
neXtProt: NX_Q96P70
Antibodypedia: Q96P70 (may not find the protein thus also not any antibody)
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