IQEC1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: IQSEC1 , ARFGEP100, BRAG2, KIAA0763
Protein names and data: IQEC1_HUMAN , IQ motif and SEC7 domain-containing protein 1 , ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; Brefeldin-resistant Arf-GEF 2 protein Lenght: 963 a.a.
Mass: 108314 Da
fasta formatted sequence

Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
Cellular location: Cytoplasm. Nucleus. Note=At steady state, may be preferentially cytosolic.
Tissue specificity: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.

Genetic variants

Database cross-references

UniProt: Q6DN90
Ensembl: ENST00000273221
MIM: 610166
neXtProt: NX_Q6DN90
Antibodypedia: Q6DN90 (may not find the protein thus also not any antibody)
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