IRF3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IRF3
Protein names and data: IRF3_HUMAN , Interferon regulatory factor 3; IRF-3 Lenght: 427 a.a.
Mass: 47219 Da
fasta formatted sequence
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Cellular location: Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.
Tissue specificity: Expressed constitutively in a variety of tissues.

Genetic variants

Database cross-references

UniProt: Q14653
Ensembl: ENST00000309877
Ensembl: ENST00000377135
Ensembl: ENST00000377139
Ensembl: ENST00000442265
Ensembl: ENST00000596765
Ensembl: ENST00000597198
Ensembl: ENST00000599223
Ensembl: ENST00000600022
Ensembl: ENST00000601291
MIM: 603734
neXtProt: NX_Q14653
Antibodypedia: Q14653 (may not find the protein thus also not any antibody)
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