ISG20_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ISG20 , HEM45
Protein names and data: ISG20_HUMAN , Interferon-stimulated gene 20 kDa protein; 3.1.13.1 , Estrogen-regulated transcript 45 protein; Promyelocytic leukemia nuclear body-associated protein ISG20 Lenght: 181 a.a.
Mass: 20363 Da
fasta formatted sequence
Function: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates.
Cellular location: Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.

Database cross-references

UniProt: Q96AZ6
Ensembl: ENST00000306072
Ensembl: ENST00000560741
MIM: 604533
neXtProt: NX_Q96AZ6
Antibodypedia: Q96AZ6 (may not find the protein thus also not any antibody)
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