Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ITGAM , CD11B, CR3A
Protein names and data: ITAM_HUMAN , Integrin alpha-M , CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; Flags: Precursor Lenght: 1152 a.a.
Mass: 127179 Da
fasta formatted sequence

Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Cellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Predominantly expressed in monocytes and granulocytes.

Genetic variants

Database cross-references

UniProt: P11215
Ensembl: ENST00000287497
Ensembl: ENST00000544665
MIM: 120980
MIM: 609939
neXtProt: NX_P11215
Antibodypedia: P11215 (may not find the protein thus also not any antibody)
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