Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ITGB2 , CD18, MFI7
Protein names and data: ITB2_HUMAN , Integrin beta-2 , Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18; Flags: Precursor Lenght: 769 a.a.
Mass: 84782 Da
fasta formatted sequence

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
Cellular location: Membrane; Single-pass type I membrane protein.

Genetic variants

Database cross-references

UniProt: P05107
Ensembl: ENST00000302347
Ensembl: ENST00000355153
Ensembl: ENST00000397850
Ensembl: ENST00000397852
Ensembl: ENST00000397857
MIM: 116920
MIM: 600065
neXtProt: NX_P05107
Antibodypedia: P05107 (may not find the protein thus also not any antibody)
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