ITPA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: ITPA , C20orf37 , My049, OK/SW-cl.9
Protein names and data: ITPA_HUMAN , Inosine triphosphate pyrophosphatase; ITPase; Inosine triphosphatase; 3.6.1.19 , Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-p Lenght: 194 a.a.
Mass: 21446 Da
fasta formatted sequence

Function: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity: A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
Disease:
Cellular location: Cytoplasm.
Tissue specificity: Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.

Genetic variants

Database cross-references

UniProt: Q9BY32
Ensembl: ENST00000380113
Ensembl: ENST00000399838
Ensembl: ENST00000455664
MIM: 147520
MIM: 613850
neXtProt: NX_Q9BY32
Antibodypedia: Q9BY32 (may not find the protein thus also not any antibody)
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