Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ITSN1 , ITSN, SH3D1A
Protein names and data: ITSN1_HUMAN , Intersectin-1 , SH3 domain-containing protein 1A; SH3P17 Lenght: 1721 a.a.
Mass: 195422 Da
fasta formatted sequence

Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Cellular location: Endomembrane system (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell projection, lamellipodium. Membrane, clathrin-coated pit. Note=Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits (Probable).
Tissue specificity: Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.

Genetic variants

Database cross-references

UniProt: Q15811
Ensembl: ENST00000379960
Ensembl: ENST00000381291
Ensembl: ENST00000381318
Ensembl: ENST00000399326
Ensembl: ENST00000399338
Ensembl: ENST00000399349
Ensembl: ENST00000399352
Ensembl: ENST00000399353
Ensembl: ENST00000399367
Ensembl: ENST00000437442
MIM: 602442
neXtProt: NX_Q15811
Antibodypedia: Q15811 (may not find the protein thus also not any antibody)
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