JAM1_HUMAN

Source: hRBCD ; ID: IPI00001754
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: F11R , JAM1, JCAM , UNQ264/PRO301
Protein names and data: JAM1_HUMAN , Junctional adhesion molecule A; JAM-A , Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321; Flags: Precursor Lenght: 299 a.a.
Mass: 32583 Da
fasta formatted sequence
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
Cellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.

Database cross-references

UniProt: Q9Y624
Ensembl: ENST00000368026
MIM: 605721
neXtProt: NX_Q9Y624
Antibodypedia: Q9Y624 (may not find the protein thus also not any antibody)
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