JIP4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SPAG9 , HSS, KIAA0516, MAPK8IP4, SYD1 , HLC6
Protein names and data: JIP4_HUMAN , C-Jun-amino-terminal kinase-interacting protein 4; JIP-4; JNK-interacting protein 4 , Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; JNK-associated leucine-zipper protein; JLP; Mitogen-activated protein kinase 8-interacting protein 4; Proliferation-inducing protein 6; Protein highly expressed in testis; PHET; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1 Lenght: 1321 a.a.
Mass: 146205 Da
fasta formatted sequence
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction.
Cellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation. Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.

Genetic variants

Database cross-references

UniProt: O60271
Ensembl: ENST00000262013
Ensembl: ENST00000357122
Ensembl: ENST00000505279
Ensembl: ENST00000510283
MIM: 605430
neXtProt: NX_O60271
Antibodypedia: O60271 (may not find the protein thus also not any antibody)
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