JOS1_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: JOSD1 , JSPH1, KIAA0063
Protein names and data: JOS1_HUMAN , Josephin-1; 3.4.19.12 , Josephin domain-containing protein 1 Lenght: 202 a.a.
Mass: 23198 Da
fasta formatted sequence
Function: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cell membrane. Cytoplasm. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquinated form may be associated with the cytoskeleton via ACTB-binding.

Genetic variants

Database cross-references

UniProt: Q15040
Ensembl: ENST00000216039
MIM: 615323
neXtProt: NX_Q15040
Antibodypedia: Q15040 (may not find the protein thus also not any antibody)
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