K1C14_HUMAN

Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: KRT14
Protein names and data: K1C14_HUMAN , Keratin, type I cytoskeletal 14 , Cytokeratin-14; CK-14; Keratin-14; K14 Lenght: 472 a.a.
Mass: 51561 Da
fasta formatted sequence

Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Disease:
Cellular location: Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern.
Tissue specificity: Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.

Genetic variants

Database cross-references

UniProt: P02533
Ensembl: ENST00000167586
MIM: 125595
MIM: 131760
MIM: 131800
MIM: 131900
MIM: 148066
MIM: 161000
MIM: 601001
neXtProt: NX_P02533
Antibodypedia: P02533 (may not find the protein thus also not any antibody)
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