Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: KRT2 , KRT2A, KRT2E
Protein names and data: K22E_HUMAN , Keratin, type II cytoskeletal 2 epidermal , Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2 Lenght: 639 a.a.
Mass: 65433 Da
fasta formatted sequence

Function: Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization.
Tissue specificity: Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

Genetic variants

Database cross-references

UniProt: P35908
Ensembl: ENST00000309680
MIM: 146800
MIM: 600194
neXtProt: NX_P35908
Antibodypedia: P35908 (may not find the protein thus also not any antibody)
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