Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: KRT1 , KRTA
Protein names and data: K2C1_HUMAN , Keratin, type II cytoskeletal 1 , 67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1 Lenght: 644 a.a.
Mass: 66039 Da
fasta formatted sequence

Function: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Cellular location: Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.
Tissue specificity: The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Genetic variants

There are two size variants of KRT1, termed allele 1A and allele 1B with allelic frequencies of 0.61 and 0.39. Allele 1B lacks 7 residues compared to allele 1A.

Database cross-references

UniProt: P04264
Ensembl: ENST00000252244
MIM: 113800
MIM: 139350
MIM: 146590
MIM: 600962
MIM: 607602
MIM: 607654
neXtProt: NX_P04264
Antibodypedia: P04264 (may not find the protein thus also not any antibody)
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