KALRN_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: KALRN , DUET, DUO, HAPIP, TRAD
Protein names and data: KALRN_HUMAN , Kalirin; 2.7.11.1 , Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain Lenght: 2985 a.a.
Mass: 340174 Da
fasta formatted sequence
Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease:
Cellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.
Tissue specificity: Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Genetic variants

Database cross-references

UniProt: O60229
Ensembl: ENST00000240874
Ensembl: ENST00000291478
Ensembl: ENST00000393496
Ensembl: ENST00000428018
MIM: 604605
MIM: 608901
neXtProt: NX_O60229
Antibodypedia: O60229 (may not find the protein thus also not any antibody)
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