Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: PRKACB
Protein names and data: KAPCB_HUMAN , cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; Lenght: 351 a.a.
Mass: 40623 Da
fasta formatted sequence

Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

Genetic variants

Database cross-references

UniProt: P22694
Ensembl: ENST00000370682
Ensembl: ENST00000370685
Ensembl: ENST00000370688
Ensembl: ENST00000370689
Ensembl: ENST00000394838
Ensembl: ENST00000394839
MIM: 176892
neXtProt: NX_P22694
Antibodypedia: P22694 (may not find the protein thus also not any antibody)
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