KBRS2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NKIRAS2 , KBRAS2
Protein names and data: KBRS2_HUMAN , NF-kappa-B inhibitor-interacting Ras-like protein 2 , I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 Lenght: 191 a.a.
Mass: 21508 Da
fasta formatted sequence
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Widely expressed.

Database cross-references

UniProt: Q9NYR9
Ensembl: ENST00000307641
Ensembl: ENST00000393880
Ensembl: ENST00000393881
Ensembl: ENST00000393885
Ensembl: ENST00000449471
Ensembl: ENST00000479407
Ensembl: ENST00000561861
Ensembl: ENST00000562265
Ensembl: ENST00000563653
Ensembl: ENST00000568696
Ensembl: ENST00000569942
Ensembl: ENST00000570113
MIM: 604497
neXtProt: NX_Q9NYR9
Antibodypedia: Q9NYR9 (may not find the protein thus also not any antibody)
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