KCNN4_HUMAN

Source: hRBCD ; ID: IPI00032466
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: KCNN4 , IK1, IKCA1, KCA4, SK4
Protein names and data: KCNN4_HUMAN , Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4 , IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel Lenght: 427 a.a.
Mass: 47696 Da
fasta formatted sequence
Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Cellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Widely expressed in non-excitable tissues.

Database cross-references

UniProt: O15554
Ensembl: ENST00000262888
MIM: 602754
neXtProt: NX_O15554
Antibodypedia: O15554 (may not find the protein thus also not any antibody)
Local full text data: click here

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