KPYM_HUMAN

Source: hRBCD ; ID: IPI00220644
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PKM , OIP3, PK2, PK3, PKM2
Protein names and data: KPYM_HUMAN , Pyruvate kinase PKM; 2.7.1.40 , Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58 Lenght: 531 a.a.
Mass: 57937 Da
fasta formatted sequence
Function: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Catalytic activity: ATP + pyruvate = ADP + phosphoenolpyruvate.
Pathway: Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 5/5.
Cellular location: Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.
Tissue specificity: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

Genetic variants

Database cross-references

UniProt: P14618
Ensembl: ENST00000319622
Ensembl: ENST00000335181
Ensembl: ENST00000389093
Ensembl: ENST00000449901
Ensembl: ENST00000565154
Ensembl: ENST00000565184
Ensembl: ENST00000568459
MIM: 179050
neXtProt: NX_P14618
Antibodypedia: P14618 (may not find the protein thus also not any antibody)
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