LAMP2_HUMAN

Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)
Gene names: LAMP2
Protein names and data: LAMP2_HUMAN , Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2 , CD107 antigen-like family member B; CD107b; Flags: Precursor Lenght: 410 a.a.
Mass: 44961 Da
fasta formatted sequence
Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
Disease:
Cellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

Genetic variants

Database cross-references

UniProt: P13473
Ensembl: ENST00000200639
Ensembl: ENST00000371335
Ensembl: ENST00000434600
MIM: 300257
MIM: 309060
neXtProt: NX_P13473
Antibodypedia: P13473 (may not find the protein thus also not any antibody)
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