LAP2_HUMAN

Source: PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ERBB2IP , ERBIN, KIAA1225, LAP2
Protein names and data: LAP2_HUMAN , Protein LAP2 , Densin-180-like protein; Erbb2-interacting protein; Erbin Lenght: 1412 a.a.
Mass: 158298 Da
fasta formatted sequence
Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
Cellular location: Cell junction, hemidesmosome. Nucleus membrane (By similarity). Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).
Tissue specificity: Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.

Genetic variants

Database cross-references

UniProt: Q96RT1
Ensembl: ENST00000284037
Ensembl: ENST00000380935
Ensembl: ENST00000380936
Ensembl: ENST00000380938
Ensembl: ENST00000380939
Ensembl: ENST00000380943
Ensembl: ENST00000506030
Ensembl: ENST00000508515
Ensembl: ENST00000511297
MIM: 606944
neXtProt: NX_Q96RT1
Antibodypedia: Q96RT1 (may not find the protein thus also not any antibody)
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