LFA3_HUMAN

Source: hRBCD ; ID: IPI00000059
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CD58 , LFA3
Protein names and data: LFA3_HUMAN , Lymphocyte function-associated antigen 3; Ag3 , Surface glycoprotein LFA-3; CD58; Flags: Precursor Lenght: 250 a.a.
Mass: 28147 Da
fasta formatted sequence
Function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.

Genetic variants

Database cross-references

UniProt: P19256
Ensembl: ENST00000369489
Ensembl: ENST00000457047
Ensembl: ENST00000464088
MIM: 153420
neXtProt: NX_P19256
Antibodypedia: P19256 (may not find the protein thus also not any antibody)
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