LGUL_HUMAN

Source: hRBCD ; ID: IPI00220766
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GLO1
Protein names and data: LGUL_HUMAN , Lactoylglutathione lyase; 4.4.1.5 , Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase Lenght: 184 a.a.
Mass: 20778 Da
fasta formatted sequence
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.
Catalytic activity: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Genetic variants

Exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties.

Database cross-references

UniProt: Q04760
Ensembl: ENST00000373365
MIM: 138750
neXtProt: NX_Q04760
Antibodypedia: Q04760 (may not find the protein thus also not any antibody)
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