Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: LIME1 , LIME , LP8067
Protein names and data: LIME1_HUMAN , Lck-interacting transmembrane adapter 1; Lck-interacting membrane protein , Lck-interacting molecule Lenght: 295 a.a.
Mass: 31288 Da
fasta formatted sequence

Function: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Cellular location: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen- presenting cell.
Tissue specificity: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).

Genetic variants

Database cross-references

UniProt: Q9H400
Ensembl: ENST00000309546
MIM: 609809
neXtProt: NX_Q9H400
Antibodypedia: Q9H400 (may not find the protein thus also not any antibody)
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