LIN7C_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: LIN7C , MALS3, VELI3
Protein names and data: LIN7C_HUMAN , Protein lin-7 homolog C; Lin-7C , Mammalian lin-seven protein 3; MALS-3; Vertebrate lin-7 homolog 3; Veli-3 Lenght: 197 a.a.
Mass: 21834 Da
fasta formatted sequence
Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Cellular location: Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.

Database cross-references

UniProt: Q9NUP9
Ensembl: ENST00000278193
MIM: 612332
neXtProt: NX_Q9NUP9
Antibodypedia: Q9NUP9 (may not find the protein thus also not any antibody)
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