LKHA4_HUMAN

Source: hRBCD ; ID: IPI00219077
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: LTA4H , LTA4
Protein names and data: LKHA4_HUMAN , Leukotriene A-4 hydrolase; LTA-4 hydrolase; 3.3.2.6 , Leukotriene A(4) hydrolase Lenght: 611 a.a.
Mass: 69285 Da
fasta formatted sequence
Function: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Catalytic activity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.
Pathway: Lipid metabolism; leukotriene B4 biosynthesis.
Cellular location: Cytoplasm.
Tissue specificity: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

Genetic variants

Database cross-references

UniProt: P09960
Ensembl: ENST00000228740
Ensembl: ENST00000413268
Ensembl: ENST00000552789
MIM: 151570
neXtProt: NX_P09960
Antibodypedia: P09960 (may not find the protein thus also not any antibody)
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