Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: LPIN2 , KIAA0249
Protein names and data: LPIN2_HUMAN , Phosphatidate phosphatase LPIN2; , Lipin-2 Lenght: 896 a.a.
Mass: 99399 Da
fasta formatted sequence

Function: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).
Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Cellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum membrane (By similarity). Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate (By similarity).
Tissue specificity: Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.

Genetic variants

Database cross-references

UniProt: Q92539
Ensembl: ENST00000261596
MIM: 605519
MIM: 609628
neXtProt: NX_Q92539
Antibodypedia: Q92539 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.