LRSM1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: LRSAM1 , TAL , UNQ6496/PRO21356
Protein names and data: LRSM1_HUMAN , E3 ubiquitin-protein ligase LRSAM1; 6.3.2.- , Leucine-rich repeat and sterile alpha motif-containing protein 1; Tsg101-associated ligase; hTAL Lenght: 723 a.a.
Mass: 83594 Da
fasta formatted sequence

Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
Pathway: Protein modification; protein ubiquitination.
Disease:
Cellular location: Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring.
Tissue specificity: Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.

Genetic variants

Database cross-references

UniProt: Q6UWE0
Ensembl: ENST00000300417
Ensembl: ENST00000323301
Ensembl: ENST00000373322
Ensembl: ENST00000373324
MIM: 610933
MIM: 614436
neXtProt: NX_Q6UWE0
Antibodypedia: Q6UWE0 (may not find the protein thus also not any antibody)
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