LSM6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: LSM6
Protein names and data: LSM6_HUMAN , U6 snRNA-associated Sm-like protein LSm6 Lenght: 80 a.a.
Mass: 9128 Da
fasta formatted sequence
Function: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
Cellular location: Cytoplasm. Nucleus (By similarity).

Database cross-references

UniProt: P62312
Ensembl: ENST00000296581
Ensembl: ENST00000502781
Ensembl: ENST00000504181
Ensembl: ENST00000515311
MIM: 607286
neXtProt: NX_P62312
Antibodypedia: P62312 (may not find the protein thus also not any antibody)
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