MAEA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MAEA , EMP , HLC10, PIG5
Protein names and data: MAEA_HUMAN , Macrophage erythroblast attacher , Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10 Lenght: 396 a.a.
Mass: 45287 Da
fasta formatted sequence
Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
Cellular location: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q7L5Y9
Ensembl: ENST00000264750
Ensembl: ENST00000303400
MIM: 606801
neXtProt: NX_Q7L5Y9
Antibodypedia: Q7L5Y9 (may not find the protein thus also not any antibody)
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