MAP2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: METAP2 , MNPEP, P67EIF2
Protein names and data: MAP2_HUMAN , Methionine aminopeptidase 2; MAP 2; MetAP 2; 3.4.11.18 , Initiation factor 2-associated 67 kDa glycoprotein; p67; p67eIF2; Peptidase M Lenght: 478 a.a.
Mass: 52892 Da
fasta formatted sequence
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Catalytic activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Cellular location: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.

Database cross-references

UniProt: P50579
Ensembl: ENST00000323666
MIM: 601870
neXtProt: NX_P50579
Antibodypedia: P50579 (may not find the protein thus also not any antibody)
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