MARK3_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: MARK3 , CTAK1, EMK2
Protein names and data: MARK3_HUMAN , MAP/microtubule affinity-regulating kinase 3; 2.7.11.1 , C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78 Lenght: 753 a.a.
Mass: 84489 Da
fasta formatted sequence
Function: Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cell membrane; Peripheral membrane protein.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: P27448
Ensembl: ENST00000216288
Ensembl: ENST00000303622
Ensembl: ENST00000416682
Ensembl: ENST00000429436
Ensembl: ENST00000440884
Ensembl: ENST00000553942
MIM: 602678
neXtProt: NX_P27448
Antibodypedia: P27448 (may not find the protein thus also not any antibody)
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