MEMO1_HUMAN

Source: hRBCD ; ID: IPI00032426
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: MEMO1 , C2orf4, MEMO, NS5ATP7 , CGI-27
Protein names and data: MEMO1_HUMAN , Protein MEMO1 , C21orf19-like protein; Hepatitis C virus NS5A-transactivated protein 7; HCV NS5A-transactivated protein 7; Mediator of ErbB2-driven cell motility 1; Mediator of cell motility 1; Memo-1 Lenght: 297 a.a.
Mass: 33733 Da
fasta formatted sequence
Function: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Database cross-references

UniProt: Q9Y316
Ensembl: ENST00000295065
Ensembl: ENST00000379383
Ensembl: ENST00000404530
Ensembl: ENST00000426310
MIM: 611786
neXtProt: NX_Q9Y316
Antibodypedia: Q9Y316 (may not find the protein thus also not any antibody)
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