MEP50_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: WDR77 , MEP50 , HKMT1069, Nbla10071
Protein names and data: MEP50_HUMAN , Methylosome protein 50; MEP-50 , Androgen receptor cofactor p44; WD repeat-containing protein 77; p44/Mep50 Lenght: 342 a.a.
Mass: 36724 Da
fasta formatted sequence
Function: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Cellular location: Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.

Genetic variants

Database cross-references

UniProt: Q9BQA1
Ensembl: ENST00000235090
MIM: 611734
neXtProt: NX_Q9BQA1
Antibodypedia: Q9BQA1 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.