MIB1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: MIB1 , DIP1, KIAA1323, ZZANK2
Protein names and data: MIB1_HUMAN , E3 ubiquitin-protein ligase MIB1; 6.3.2.- , DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; Zinc finger ZZ type with ankyrin repeat domain protein 2 Lenght: 1006 a.a.
Mass: 110136 Da
fasta formatted sequence

Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Pathway: Protein modification; protein ubiquitination.
Disease:
Cellular location: Cytoplasm. Cell membrane (By similarity). Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear.
Tissue specificity: Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

Genetic variants

Database cross-references

UniProt: Q86YT6
Ensembl: ENST00000261537
MIM: 608677
MIM: 615092
neXtProt: NX_Q86YT6
Antibodypedia: Q86YT6 (may not find the protein thus also not any antibody)
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