MIF_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MIF , GLIF, MMIF
Protein names and data: MIF_HUMAN , Macrophage migration inhibitory factor; MIF; 5.3.2.1 , Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; 5.3.3.12; Phenylpyruvate tautomerase Lenght: 115 a.a.
Mass: 12476 Da
fasta formatted sequence
Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Catalytic activity: Keto-phenylpyruvate = enol-phenylpyruvate. L-dopachrome = 5,6-dihydroxyindole-2- carboxylate.
Disease:
Cellular location: Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.

Database cross-references

UniProt: P14174
Ensembl: ENST00000215754
MIM: 153620
MIM: 604302
neXtProt: NX_P14174
Antibodypedia: P14174 (may not find the protein thus also not any antibody)
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