MINK1_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MINK1 , B55, MAP4K6, MINK, YSK2, ZC3
Protein names and data: MINK1_HUMAN , Misshapen-like kinase 1; 2.7.11.1 , GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6 Lenght: 1332 a.a.
Mass: 149822 Da
fasta formatted sequence
Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Isoform 4: Golgi apparatus.
Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.

Genetic variants

Database cross-references

UniProt: Q8N4C8
Ensembl: ENST00000347992
Ensembl: ENST00000355280
Ensembl: ENST00000453408
MIM: 609426
neXtProt: NX_Q8N4C8
Antibodypedia: Q8N4C8 (may not find the protein thus also not any antibody)
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