MINP1_HUMAN

Source: hRBCD ; ID: IPI00028553
PM19886704
PM23856902
BSc_CH
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: MINPP1 , MIPP , UNQ900/PRO1917
Protein names and data: MINP1_HUMAN , Multiple inositol polyphosphate phosphatase 1; 3.1.3.62 , 2,3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; 3.1.3.80; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase; Flags: Precursor Lenght: 487 a.a.
Mass: 55051 Da
fasta formatted sequence
Function: Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification).
Catalytic activity: Myo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate. 2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate.
Disease:
Cellular location: Endoplasmic reticulum lumen (By similarity).
Tissue specificity: Widely expressed with highest levels in kidney, liver and placenta.

Genetic variants

Database cross-references

UniProt: Q9UNW1
Ensembl: ENST00000371994
Ensembl: ENST00000371996
Ensembl: ENST00000536010
MIM: 605391
neXtProt: NX_Q9UNW1
Antibodypedia: Q9UNW1 (may not find the protein thus also not any antibody)
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