MKRN1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MKRN1 , RNF61
Protein names and data: MKRN1_HUMAN , E3 ubiquitin-protein ligase makorin-1; 6.3.2.- , RING finger protein 61 Lenght: 482 a.a.
Mass: 53349 Da
fasta formatted sequence
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Pathway: Protein modification; protein ubiquitination.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9UHC7
Ensembl: ENST00000255977
Ensembl: ENST00000443720
Ensembl: ENST00000474576
MIM: 607754
neXtProt: NX_Q9UHC7
Antibodypedia: Q9UHC7 (may not find the protein thus also not any antibody)
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