MOB1A_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MOB1A , C2orf6, MOB4B, MOBK1B, MOBKL1B
Protein names and data: MOB1A_HUMAN , MOB kinase activator 1A , Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B Lenght: 216 a.a.
Mass: 25080 Da
fasta formatted sequence
Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.

Database cross-references

UniProt: Q9H8S9
Ensembl: ENST00000396049
MIM: 609281
neXtProt: NX_Q9H8S9
Antibodypedia: Q9H8S9 (may not find the protein thus also not any antibody)
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